Syndrome W Publications & Presentations

2015: A modified carbohydrate diet and insulin sensitizers that reduce body weight

A modified carbohydrate diet and insulin sensitizers that reduce body weight

Dr. Mogul authored a studied called "Carbohydrate Modified Diet & Insulin Sensitizers Reduce Body Weight & Modulate Metabolic Syndrome Measures in EMPOWIR (Enhance the Metabolic Profile of Women with Insulin Resistance): A Randomized Trial of Normoglycemic Women with Midlife Weight Gain"

Authors: Harriette R. Mogul , Ruth Freeman, Khoa Nguyen, Michael Frey, Lee-Ann Klein, Sheila Jozak, Karen Tanenbaum

Source: Department of Medicine, Division of Endocrinology, New York Medical College, 19 Skyline Dr., Hawthorne, New York 10532, USA. hrmogul@nymc.edu

CONTEXT: Progressive midlife weight gain is associated with multiple adverse health outcomes and may represent an early manifestation of insulin resistance in a distinct subset of women. Emerging data implicate hyperinsulinema as a proximate cause of weight gain and support strategies that attenuate insulin secretion.

Objectives: To assess a previously reported novel hypocaloric carbohydrate modified diet alone (D), and in combination with metformin (M) and metformin plus low-dose rosiglitazone (MR), in diverse women with midlife weight gain (defined as >20lbs since the twenties), normal glucose tolerance, and hyperinsulinemia.

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