Long-Term (2-4 Year) Weight Reduction With Metformin Plus Carbohydrate - Modified Diet in Euglycemic, Hyperinsulinemic, Midlife Women (Syndrome W)
By Harriette R. Mogul, MD, MPH, Stephen J. Peterson, MD, Bernard I. Weinstein, PhD, Jianyu Li, MD, MS, and A. Louis Southern, MD
Long-term weight reduction remains the ultimate objective and challenge of obesity management.
Dr. Mogul authored a study entitled "Long-term (2-4 year) weight reduction with metformin plus carbohydrate-modified diet in euglycemic, hyperinsulinemic, midlife women (Syndrome W)."
Authors: Mogul HR, Peterson SJ, Weinstein BI, Li J, Southren AL
Source: Divisions of Endocrinology, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA. [email protected]
Abstract
Long-term weight reduction remains the ultimate objective and challenge of obesity management. Few long-term dietary or pharmacointervention studies have been conducted and there is a critical need for long-range treatment strategies that are effective, safe, and acceptable. The authors conducted a retrospective cohort analysis of 21 euglycemic, hyperinsulinemic women with progressive, refractory, midlife weight gain (Syndrome W) who had previously lost weight (> or =10% reduction from baseline) with a comprehensive 1-year treatment program that included metformin and a hypocaloric, carbohydrate-modified (low-glycemic index) diet, as well as, other lifestyle modifications.
